The paper presents the results of studying the dynamics of life meaning orientations in individuals with opioid dependence involved in the rehabilitation programs of religious and secular type. The study revealed that the process of qualitatively organized inpatient spiritually oriented rehabilitation program (SORP) allows you to change the individual drug addicts in the general sections of the meaningfulness of life, purpose and significance in the process of living, meeting process, the meaningfulness of the past, present and future, as well as the impact of life to a greater extent than would be possible to make a non-religious therapy communities. In the SORP the dynamics of subscales “locus of control — I” and “locus of control — the life” are poorly expressed, in some cases negative, indicating a need to connect the programs aimed at developing participants rehabilitants rehabilitation programs and degree levels of self-responsibility for the study and solution of life’s goals and objectives.