The article is focused on the opportunities of further development of L.S. Vygotsky’s and A.R. Luria’s cultural-historical approach. Two of them are researched: 1) further analysis of symbolic mediation methods of psyche in the modern society and its social and cultural stratification and 2) cultural-historical analysis use in research of theories and conceptual apparat of clinical psychology. The necessity of understanding knowledge in clinical psychology in the context of its cultural-historical experience formation is proved. The importance of such analysis is shown for research of development conditions of such knowledge, its borders, functions and define historical sense, that contributes to the deeper understanding of psychological clinic and psychotherapy.