Relevance. It is stressed that the structural-integrative approach for human functional states’ analysis, elaborated at the end of 80s on the base of system analysis of work activity, formed the appropriate theoretical frame for evaluation and prediction of workability and reliability alteration. At present, in innovative work environment, this approach is still the adequate base for urgent and challenging issues, both scientific and practical, such as analysis of work activity regulation mechanisms in tensed work situations; evaluation of a state’s self-regulation in work conditions under long-term strain; elaboration of applied programs for the development of adaptation resources.

Objective. The article focuses on the basic issues of the structural-integrative approach, where a state is defined as a special structure of inner means for tasks execution regulation, acquired by a subject under specific work conditions to human functional states’ analysis. The main aim – the estimation of the approach capabilities for human functional states’ investigations in modern organizational and professional environment.

Method. Methods of multilevel assessment of a functional state’s manifestation are analyzed. The possibilities of data integration technologies, used for different functional states identification, are discussed. The different technologies for self-regulation of a state are viewed taking in account their capabilities to develop and improve the individual adaptation potential in work.

Results. The results of the main research based on the structural-integrative approach is overviewed. Special attention is given to the following question: is the structural-integrative approach worth implementation for the evaluation of a human functional state in applied research, when it is not possible to get data about manifestations of a state on all necessary levels - physiological, psychological (including cognitive and subjective sublevels) and behavioral. The example of such research is presented. 

Conclusions. The results ofmore than 30 years of the structural-integrative approach implementation proved its efficiency for human functional states’ evaluation in dynamic work environment. The possibilities of the approach for functional states’ analysis under work conditions of high autonomy and self-determination in work tasks planning and execution are defined.