The results of complex neuropsychological examination of the subjects with various pathologies of the corpus callosum (CC) conducted by the author are analyzed in the article. In the survey were used method for the study of the formation of fixed installation in haptic sphere and perceptive priming method. The goal of the study was development of one of neuropsychological factors of hemispheric interaction. Split Brain Syndrome characterized as a neuropsychological syndrome and the symptoms of higher mental functions violations in patients with various pathologies of the CC are described. The author describes the primary symptoms of hemispheric interaction violations caused by commissure pathology. Second part of the paper discusses the point of view of domestic and foreign researchers on the functional role of cerebral hemispheres, their front and rear parts in the human psyche and behavior. In the third part of the article the author describes neuropsychological factor interhemispheric interaction associated with the CC activity. This factor is a syndrome-forming with the CC pathology of various origins. It is integrative as the result of cooperation of two associative brain areas. It could be determined as the factor of formation and reproduction of behavioral acts or psyche selfdetermination factor.