The empirical study of self-regulation means was conducted in employees with different levels of professional experience. The relevance of the study is based on the necessity of scientific data storage concerning human functional state regulation mechanisms. The aim — to reveal main job and organizational factors accepted by employees as the main causes of negative functional states dynamics, to describe the system of self-regulation means and to estimate how typical means correspond to organizational requirements. The results show that the novices tend to activate asocial and aggressive coping behavior as a response to emotional communications with clients and permanent work interruptions. Experienced employees report about more healthy typical coping means that are used in strict conformity with accepted organizational rules.