Relevance of the research is based on the development of modern technological innovative organizations, dynamic organizational environment and job stressors connected with inaction of human adoptive processes which provoke professional deformations in employees.

Objective. To provide theoretical, methodological and empirical base of professional deformations’ research in innovative sphere professions as the situation of development of destructive or adoptive job performance mechanisms.

Methodology. 927 subjects, innovative sphere professionals, took part in the study. To obtain data were used: Managerial Stress Survey (Leonova, 2006); means to assess the modality specific professional deformations as a base of self-management programs; psychological self-regulation methods.

Results. It was found the job conditions and job content in innovative sphere professions that predicted the risk group of professional deformations’ development. Chronic professional stress manifestations (anxiety, exhaustion, aggressive and depressive behavior tendencies) were found as predictors professional deformations in innovative sphere employees. The mechanisms of modality specific professional deformations were analyzed; the effectiveness of different integrative image based psychological self-regulation methods is connected with adoptive modality specific professional deformations in innovative sphere employees.

Conclusions. The principle of professional deformations’ development in innovative sphere employees is based on cumulative effect of acute job stress and chronic job stress syndrome. Destructive professional deformations and adoptive modality specific professional deformations in employees develop on the influence of job demands in innovative sphere professions.