The paper is devoted to consideration of the main research domains on the problems of human reliability and stress management that recently developed in the Laboratory of work psychology (Faculty of Psychology, Moscow State University). There are discussed a new paradigm for the structural analysis of worker’s functional states and a hierarchical model of occupational stress elaborated in the framework of Leontiev’s activity theory. The appropriate set of criteria and methods for evaluation of personnel mental health and efficiency of organizational interactions were produced as a basis for creating goal-oriented stress management technologies, i.e. «Personal diagnostic and prevention of stress», «Assessment of the individual level of stress-resistance», «Self-regulation training and restoration program». They were carried out as the complex systems that provide a support in the work of psychologists in practice and demonstrate an efficient way of integrating the new conceptual approaches to the modern issues in the field of work, organizational and health psychology.