In article the basic results received by E.N. Sokolov in experiences on studying of mechanisms of memory are presented. E.N. Sokolov has developed a system of experiments helped to refine the analysis of the mechanisms of memory. As experimental model of memory the habituation was used and as research methods various objective indicators of work of a brain — from EEG to intracellular potentials of single neuronswere applied. The experiments gave the possibility to formulate the concept of nervous model of stimuli and synaptic potentiation as a basis for remembering the properties of an effective signal. This article gives a brief overview of these works.